Billionaire investor Isaacman has been formally approved as the next chief of NASA, capping an extraordinary confirmation journey where the President nominated him, withdrew it, and then renominated him.
Isaacman, an amateur jet pilot who was the first private citizen to undertake a spacewalk, is also the first NASA administrator in many years to come straight from the private sector.
For a significant portion of the space community, the legacy of his tenure will be determined by one crucial test: its ability to land people to the lunar surface in advance of the Chinese space program.
The administration has made clear a goal for the US to create a sustained presence on the moon, both to enable harvesting materials and to serve as a launching pad for travel to the Red Planet.
On Wednesday, the U.S. Senate cleared Isaacman's nomination with a 67-30 vote.
The President first withdrew the nomination in the spring, pointing to a "comprehensive examination of past connections".
At the point, the president was openly clashing with Elon Musk, one of his major contributors, with whom Isaacman has a working relationship.
Isaacman says he is now fully behind the administration's goal to extract lunar resources, putting him at odds with Elon Musk, who has stated that lunar missions is a diversion from the goal of Martian exploration.
In the present global space race, countries are vying to exploit the lunar surface.
“Now is not the time for delay but a time for decisive steps because if we fall behind, if we err, we may never catch up, and the results could change the global dynamics here on our planet,” he told lawmakers during his hearing.
The business leader sees bringing in more industry players as key to meeting those targets, according to a recently disclosed memo detailing his plan for the agency.
In his confirmation hearing, he supported the plan, which he crafted when he was first nominated, but noted it was a developing document.
His support for competition could also lead to tension with SpaceX. Last week, Isaacman commended the issuance of a significant agreement to Blue Origin, which is one of the primary competitors of SpaceX.
In the strategy paper, he proposed NASA should expand collaboration with universities and academic institutions, positioning the agency as a "amplifier for research".
He highlighted the planned deployment of the Nancy Grace Roman Space Telescope as a prime illustration.
"And if we be on the verge of something remarkable - like launching Roman - I will leave no stone unturned to see it launched, even using my own resources if that's what it takes to produce the science," he remarked.
According to estimates, his fortune is pegged at around $1.2 billion, accumulated through his financial services firm and the divestment of his business that trained pilots and operated a private fleet of military jets.
The NASA administrator role will be his initial foray in government service, a break from the immediate predecessors who served as NASA chief.
He will take over from the former transportation secretary, who has been the acting administrator since July.
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